Please read: Metformin and myo-inositol serve a similar function. There is no purpose in taking both if you are not going to be weaning off of one. [Diet, metformin and inositol in overweight and obese women with polycystic ovary syndrome: effects on body composition]. [Article in Italian] Le Donne M(1), Alibrandi A, Giarrusso R, Lo Monaco I, Muraca U. Myo-Inositol can be converted to D-chiro-inositol in the body (D-chiro-inositol is one of the 9 isomers along with myo-inositol). So, supplementing with either one should be effective in managing some of your PCOS symptoms. If you’ve been following the PCOS Nutrition Center blog, you know what a fan we are of a combination of myo and d-chiro inositol (DCI) for pretty much any woman with PCOS, regardless of age or fertility. While myo-inositol on its own is the most widely studied form of this supplement for women with PCOS, new products that combine both myo and D-chiro forms of inositol have been promoted heavily since about 2013 as I discuss more below. By Amy Medling, founder of PCOS Diva. Lately, myo- inositol seems to be the other “m”-word in the PCOS world (the first being metformin). There is a lot of very positive research coming out about myo-inositol and how it helps women with PCOS. a comparative study of myo inositol versus metformin on biochemical profile in polycystic ovarian syndrome in women html full text. a comparative study of myo inositol versus metformin on biochemical profile in polycystic ovarian syndrome in women Rizzo P., Raffone E., Benedetto V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. The aim of this study is to compare the effects of six months treatment of two insulin-lowering therapies on the clinical and endocrine-metabolic parameters in obese women affected by polycystic ovary syndrome.